Orforglipron: The Oral GLP-1 That Could Change the Weight Loss Market
Big news is emerging from the European Association for the Study of Diabetes (EASD) this week. Results from the pivotal ATTAIN-1 phase 3 trial were just published in the New England Journal of Medicine, shining a spotlight on orforglipron — a once-daily oral GLP-1 receptor agonist being called an “oral Ozempic.”
If approved, orforglipron could hit the market by the end of this year, giving patients a new, pill-based option for weight management.
How Orforglipron Performed
In the 72-week trial, participants taking orforglipron lost an average of ~11% of their body weight. While some injectable GLP-1 medications (like Wegovy and Zepbound) show higher averages, the convenience of an oral option makes this therapy especially exciting.
How It Compares to Current Options
Here’s how orforglipron stacks up against other FDA-approved medications for weight management:
Contrave: ~4–5% average weight loss
Saxenda (now also available as a generic): ~6–7%
Qsymia: ~10–11%
Orforglipron (new oral GLP-1): ~11%
Wegovy (injectable semaglutide): ~15%
Zepbound (injectable tirzepatide): ~20%
Why This Matters
GLP-1 receptor agonists have already transformed the landscape of obesity and diabetes care. However, for many patients, injections are a barrier — whether due to cost, convenience, or personal preference. An oral GLP-1 option could expand access and improve adherence for those who need it most.
While orforglipron’s weight loss results may not reach the level of Wegovy or Zepbound, its convenience, safety profile, and potential affordability make it an important step forward.
What This Means for Patients
At Endocrine Advantage, we closely follow advancements like this to bring the best options to our patients. If approved, orforglipron may become a valuable addition to weight management plans, particularly for those seeking non-injectable therapies.
Ready to Learn More?
Whether you’re exploring weight loss treatments for the first time or want to understand the latest options, our team is here to guide you.
📞 Call us today at (909) 757-8078 or visit our website to schedule your appointment. Let’s find the plan that works best for you.
